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Burkhard Schlosshauer
Prof. Dr. Burkhard Schlosshauer
Diplom-Biochemiker
Immunologie an Grenzflächen
Tel.: 07121 51530-20
Fax: 07121 51530-16

Forschungsinteressen/Arbeitsgebiete
Neuronale und Gefäß-Regeneration, Blut-Hirn schranke, Fibrose/Adhäsion, Regenerative Medizin, Implantatentwicklung

Wissenschaftlicher Werdegang mit den wichtigsten Stationen        
- Studium Biochemie
- Postdoktorand, Yale Universität, New Haven, USA
- Wissenschaftlicher Mitarbeiter, Max-Planck-Institut für Entwicklungsbiologie, Tübingen
- Max-Planck-Gästelabor, Institut für Zellbiologie, Academia Sinica, Shanghai, China
- Habilitation (Zellbiologie) Universität Tübingen
- apl. Professor, Universität Tübingen
- NMI Leiter Regenerative Medizin I;     

Lehrtätigkeit
Graduate School of Cellular and Molecular Neurosciences
Studiengang Biologie (BSc, MSc) Universität Tübingen
sieben Lehrpreise

Publikationen

Hartmann, H., Schlosshauer, B. (2014).
Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactions
In: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.

Gutoaia, A., Schuster, L., Margutti, S., Laufer, S., Schlosshauer, B., Krastev, R., Stoll, D., Hartmann, H. (2016).
Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity
Carbohydrate Polymers (in press).

Schuster, L., Seifert, O., Vollmer, S., Kontermann, R. E., Schlosshauer, B., Hartmann, H. (2015).
Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.

Hartmann, H., Hoehne, K., Rist, E., Louw, A. M., Schlosshauer, B. (2015).
miR-124 disinhibits neurite outgrowth in an inflammatory environment
Cell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.

Schuster, L., Seifert, O., Vollmer, S., Kontermann, R.E., Schlosshauer, B., Hartmann, H. (2015).
Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
Molecular Pharmaceutics

Aberle, T., Franke, K., Rist, E., Benz, K., Schlosshauer, B. (2014).
Cell-type specific four-component hydrogel
PLoS One. 2014 Jan 27;9(1):e86740. doi: 10.1371/journal.pone.0086740. eCollection 2014.

Hartmann, H., Hossfeld, S., Schlosshauer, B., Mittnacht, U., Pego, A. P., Dauner, M., Doser, M., Stoll, D., Krastev, R. (2013).
Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes
J Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.

Franke, K., Baur, M., Daum, L., Vaegler, M., Sievert, K. D., Schlosshauer, B. (2013).
Prostate carcinoma cell growth-inhibiting hydrogel supports axonal regeneration in vitro
Neurosci Lett. 2013 Apr 29;541:248-52. doi: 10.1016/j.neulet.2013.01.057. Epub 2013 Feb 15.

Hossfeld, S., Nolte, A., Hartmann, H., Recke, M., Schaller, M., Walker, T., Kjems, J., Schlosshauer, B., Stoll, D., Wendel, H. P., Krastev, R. (2013).
Bioactive coronary stent coating based on layer-by-layer technology for siRNA release
Acta Biomater. 2013 Jan 17. pii: S1742-7061(13)00019-6. doi: 10.1016/j.actbio.2013.01.013.

Baumer, Y., Leder, C., Ziegler, M., Schonberger, T., Ochmann, C., Perk, A., Degen, H., Schmid-Horch, B., Elvers, M., Munch, G., Ungerer, M., Schlosshauer, B., Gawaz, M. (2012).
The recombinant bifunctional protein alphaCD133-GPVI promotes repair of the infarcted myocardium in mice
J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x.

Ziegler, M., Elvers, M., Baumer, Y., Leder, C., Ochmann, C., Schonberger, T., Jurgens, T., Geisler, T., Schlosshauer, B., Lunov, O., Engelhardt, S., Simmet, T., Gawaz, M. (2012)
The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice
Circulation Feb 7;125(5):685-96. Epub 2012 Jan 5

Sinis, N., Kraus, A., Drakotos, D., Doser, M., Schlosshauer, B., Muller, H. W., Skouras, E., Bruck, J. C., Werdin, F. (2011)
Bioartificial reconstruction of peripheral nerves using the rat median nerve model
Ann Anat. 2011 Jul;193(4):341-6. Epub 2011 Mar 22.

Kubon, M., Moschallski, M., Link, G.S., Werner, S., Burkhardt, C., Nisch, W., Scholz, B., Schlosshauer, B., Urban, G., Stelzle, M. (2010)
Ex ovo culture: An in vivo model for microsensorarray implants
7th International Meeting on Substrate-Integrated Microelectrode Arrays Reutlingen, NMI, BioPro.

Baumer, Y., Scholz, B., Ivanov, S., Schlosshauer, B. (2011)
Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells
Exp Biol Med (Maywood). 2011 Jun 1;236(6):692-700. Epub 2011 May 9.

Hoffmann, N., Mittnacht, U., Hartmann, H., Baumer, Y., Kjems, J., Oberhoffner, S., Schlosshauer, B.(2011)
Neuronal and glial responses to siRNA-coated nerve guide implants in vitro
Neurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23.

Schlosshauer, B., Mittnacht, U. (2010)
Tissue Engineering peripherer Nerven
Regenerative Medizin.

Hartmann, H., Schlosshauer, B. (2010)
Fremdkörper-Reaktionen auf Biomaterialien und Strategien zum Funktionserhalt von Implantaten
BIOmaterialien 2010; 11 (November): S. 15-23

Nichterwitz, S., Hoffmann, N., Hajosch, R., Oberhoffner, S., Schlosshauer, B. (2010)
Bioengineered glial strands for nerve regeneration
Neurosci Lett. 2010 Oct 29;484(2):118-22. Epub 2010 Aug 17.

Mittnacht, U., Hartmann, H., Hein, S., Oliveira, H., Dong, M., Pego, A. P., Kjems, J., Howard, K. A., Schlosshauer, B. (2010)
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth
Nano Lett. 2010 Oct 13;10(10):3933-9.

Hajosch, R., Suckfuell, M., Oesser, S., Ahlers, M., Flechsenhar, K., Schlosshauer, B. (2010)
A novel gelatin sponge for accelerated hemostasis
J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):372-9.

Scholz, B., Kinzelmann, C., Benz, K., Mollenhauer, J., Wurst, H., Schlosshauer, B. (2010)
Suppression of adverse angiogenesis in an albumin-based hydrogel for articular cartilage and intervertebral disc regeneration
Eur Cell Mater. 2010 Jul 13;20:24-36; discussion 36-7.

Baumer, Y., Funk, D., Schlosshauer, B. (2010)
Does telomerase reverse transcriptase induce functional de-differentiation of human endothelial cells?
Cell Mol Life Sci. 2010 Mar 30.

Hajosch, R., Grupp, L., Nichterwitz, S., Schlosshauer, B. (2010)
A novel microsurgical nerve implantation technique preserving outer nerve layers
J Neurosci Methods. 2010 Apr 14.

Ribeiro-Resende, V. T., Koenig, B., Nichterwitz, S., Oberhoffner, S., Schlosshauer, B. (2009)
Strategies for inducing the formation of bands of Büngner in peripheral nerve regeneration
Biomaterials. 2009 Oct;30(29):5251-9. Epub 2009 Jul 26.

Dreesmann, L., Mittnacht, U., Lietz, M., Schlosshauer, B. (2009)
Nerve fibroblast impact on Schwann cell behavior
Eur J Cell Biol. 2009 Feb 24.

Dreesmann, L., Hajosch, R., Ahlers, M., Nuernberger, J. V., Schlosshauer, B. (2008)
Permeability testing of biomaterial membranes
Biomed Mater. 2008 Sep;3(3):034119. Epub 2008 Aug 15.

Ruettger, A., Schueler, S., Mollenhauer, J.A., Wiederanders, B. (2008)
Cathepsins B, K and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes
J Biol Chem. 2008 Jan 11;283(2):1043-51. Epub 2007 Nov 8.

Storn, V., Kirschbaum, M., Schlosshauer, B., Mack, A. F., Fricke, C. (2008)
Electrical stimulation-induced release of beta-endorphin from genetically modified neuro-2a cells.
Cell Transplant. 2008;17(5):543-8.

Schlosshauer, B. (2007)
Nervenregeneration
Zeitschrift für Regenerative Medizin, Issue 1, p. 45-49

Dreesmann, L., Ahlers, M., Schlosshauer, B. (2007)
The pro-angiogenic characteristics of a cross-linked gelatin matrix
Biomaterials. 2007 Dec;28(36):5536-43. Epub 2007 Sep 21.

Steffensky, M., Steinbach, K., Schwarz, U., Schlosshauer, B. (2006)
Differential impact of semaphorin 3E and 3A on CNS axons.
Int J Dev Neurosci. 2006 Feb;24(1):65-72. Epub 2005 Dec 9.

Dreesmann, L., Ahlers, M., Schlosshauer, B. (2007)
The pro-angiogenic characteristics of a cross-linked gelatin matrix.
Biomaterials. 2007 Dec;28(36):5536-43. Epub 2007 Sep 21.

Schlosshauer, B. (2007)
Blood-retina barriers
Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition, Vol. 11 Neural Membranes and Transport (Ed. A. Lajtha and M.E.A Reith), Springer Publishers, New York, Springer Publishers N.Y., pages 486-506.

Sinis, N., Schaller, H.-E., Schulte-Eversum, C., Becker, S. T., Schlosshauer, B., Doser, M., Rösner H., Dietz, K., Müller H.-W., Haerle, M. (2007)
Long nerve gaps limit the regenerative potential of bioartificial nerve conduits filled with Schwann cells
Restor Neurol Neurosci. 25 (2), pages 131-41

Funk, D., Fricke, C., Schlosshauer, B. (2007)
Aging Schwann cells in vitro
Eur J Cell Biol. 2007 Apr;86(4):207-19. Epub 2007 Feb 20.

Sinis, N., Schaller, H. E., Schulte-Eversum, C., Schlosshauer, B., Doser, M., Dietz, K., Rosner, H., Muller, H. W., Haerle, M. (2006)
Tissue engineering of peripheral nerves
Handchir Mikrochir Plast Chir. 2006 Dec;38(6):378-89.

Steuer, H., Jaworski, A., Stoll, D., Schlosshauer, B. (2004)
In vitro model of the outer blood-retina barrier
Brain Res Brain Res Protoc. 2004 Apr;13(1):26-36.

Schlosshauer, B., Muller, E., Schroder, B., Planck, H., Muller, H. W. (2003)
Rat Schwann cells in bioresorbable nerve guides to promote and accelerate axonal regeneration
Brain Res. 2003 Feb 14;963(1-2):321-6.

van Bergen, A., Papanikolaou, T., Schuker, A., Moller, A., Schlosshauer, B. (2003)
Long-term stimulation of mouse hippocampal slice culture on microelectrode array
Brain Res Brain Res Protoc. 2003 May;11(2):123-33.

Helle, T., Deiss, S., Schwarz, U., Schlosshauer, B. (2003)
Glial and neuronal regulation of the lipid carrier R-FABP
Exp Cell Res. 2003 Jul 1;287(1):88-97.

Steffensky, M., Steinbach, K., Schwarz, U., Schlosshauer, B. (2006)
Differential impact of semaphorin 3E and 3A on CNS axons
Int J Dev Neurosci. 2006 Feb;24(1):65-72. Epub 2005 Dec 9.

Sinis, N., Schaller, H. E., Schulte-Eversum, C., Schlosshauer, B., Doser, M., Dietz, K., Rosner, H., Muller, H. W., Haerle, M. (2005)
Nerve regeneration across a 2-cm gap in the rat median nerve using a resorbable nerve conduit filled with Schwann cells.
J Neurosurg. 2005 Dec;103(6):1067-76.

Schlosshauer, B., Lietz, M. (2004)
Nerve Guides
Encyclopedia of Biomaterials and Biomadical Engineering, p. 1043-1045, DOI: 10.1081/E-EBBE 120007361.

Schlosshauer, B., Steuer, H. (2005)
The Blood-brain Barrier and the Outer Blood-retina Barrier
Medicinal Chemistry Reviews - Online, Vol. 1, page 11-26.

Steuer, H., Jaworski, A., Elger, B., Kaussmann, M., Keldenich, J., Schneider, H., Stoll, D., Schlosshauer, B. (2005)
Functional Characterization and Comparison of the Outer Blood-Retina Barrier and the Blood-Brain Barrier.
Invest Ophthalmol Vis Sci. 2005 Mar;46(3):1047-53.

Schlosshauer, B., Dreesmann, L., Schaller, H. E., Sinis, N. (2006)
Synthetic Nerve Guide Implants in Humans: A Comprehensive Survey
Neurosurgery. 2006 Oct;59(4):740-7; discussion 747-8.

Lietz, M., Ullrich, A., Schulte-Eversum, C., Oberhoffner, S., Fricke, C., Muller, H. W., Schlosshauer, B. (2006)
Physical and biological performance of a novel block copolymer nerve guide.
Biotechnol Bioeng. 2006 Jan 5;93(1):99-109.

Lietz, M., Dreesmann, L., Hoss, M., Oberhoffner, S., Schlosshauer, B. (2006)
Neuro tissue engineering of glial nerve guides and the impact of different cell types.
Biomaterials. 2006 Mar;27(8):1425-36. Epub 2005 Sep 19.

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