BioMEMS / Sensors
- BioMEMS (Bio-Microelectromechanical Systems) for applications in diagnostics and therapy
- Development of electrochemical and optical sensors
- Functional coatings, micropatterned surface functionalization
- Micro- and nanotechnology
- Dielectrophoretic manipulation of particles in microfluidic systems, bioseparation
- Multiphysics simulation of field distribution, hydrodynamic and electric forces, transport processes in microsystems
Techniques, methods, equipment
- Sensor laboratory for preparation and evaluation of sensors, electrochemistry setups, impedance spectroscopy
- Thick film printing setup
- Microfluidic laboratory with experimental setups comprising fluorescence microscopes, cameras, microfluidic controllers with LabView interface
- Chemistry laboratory with Glovebox, instrumentation for surface functionalization
- CAD/CAM systems for rapid prototyping of microsystems, preparation of molds
- Fineplacer, adhesive bonding system
- Multiphysics simulation software (CFD-ACE, FlexPDE)
- Microcontact printing (CAD-design, mold fabrication, stamps, alignment tools)
Services
- Multiphysics simulation, support for development of microfluidic devices
- Thickfilm technology and sensor development
- Microcontact printing (CAD-design, mold fabrication, stamps, alignment tools)
- Versatile Microfluidic Controller System, incl. control software
Projects
Completed:
NanoBioPore: nanoporous electrode systems for sensitive electrochemical sensors for medical diagnostics
Artificial Synapse: chemical stimulation of cells and tissues by localized application of compounds from a microfluidic system
microPrep:subcellular fractionation of cell homogenates by dielectrophoretic forces in a microfluidic system, robust longterm stable fractionation to yield ultra-pure organelle preparations for proteom analysis (2D-PAGE, MS)
Nanohybrid: nano-patterning technology based on the self-organisation of nanoparticles and their use as shadow masks (download further information)
PathIdent: microfluidic diagnostic system for the detection of antibiotic resistance genes (winner project at the BMBF innovation contest for medical technology 2006)
HepaChip: microfluidic 3D cell culture system for assembly of liver sinusoids from primary cells and use for repeated dose toxicity testing
ImplantMon: implantable microsensorarray to monitor physiological parameters at the sensor / tissue interface during ingrowth (download information 1 / information 2)
Ci-Ca: electrochemical microsensors to monitor citrate anti-coagulation during extracorporal blood treatment
On going
Functional coatings: tailoring material surfaces to enhance and guide interaction of cells and tissuess.
SafeIS: immunoassay in a microfluidic cartridge to measure the effectiveness of immune suppressiva in samples from patients´ blood (download further information)
VirCellChip: microfluidic diagnostic platform to specifically accumulate and detect cells or viruses in blood without PCR
ChamPArray: sensitive detection of DNA in microfluidic system
Click&Go: sensors for cassette based blood gas analyzer system
NanoPORElution: nano-porous drug delivery device technology, application to coronary stents
Aptamer Copolymers: bioseparation device to separate cells from aptamer molecules