Reduction of animal testing through new in vivo biomaterial testing
New in vivo biomaterial testing methods are to significantly reduce animal testing for examining implantable biomaterials. This is the goal pursued by the joint project of the EU, Biomaterial Implant Monitoring Test or, in short, BiMoT, carried out by NMI, the Natural and Medical Sciences Institute at the University of Tübingen. The project focuses on the development of a new sensor-based method for determining biocompatibility in order to reduce in the future the number of so far indispensable animal tests when developing new biomaterials and, at the same time, it helps examine large numbers of new biofunctional biomaterials. Basis of this new testing system is a micro sensor implant that continuously measures a material’s biocompatibility, over its entire implant period, so allowing the monitoring, quantification and classification of the ingrowth behavior of biomaterial in soft tissue by the material developer.